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Schematic Diagram of the Preparation of AM-Alg-APA Self-Assembled Micelles through Acylation Reaction as a Potential Hydrophobic Drug Carrier for Functional Medical Dressings

Journal: ACS Omega

Article Title: Self-Assembly of Alginate-Grafted Penicillanic Acid Derivatives into Antibacterial Micelles for Controlled Drug Delivery

doi: 10.1021/acsomega.5c10841

Figure Lengend Snippet: Schematic Diagram of the Preparation of AM-Alg-APA Self-Assembled Micelles through Acylation Reaction as a Potential Hydrophobic Drug Carrier for Functional Medical Dressings

Article Snippet: The morphology of the resulting AM-Alg-APA self-assembled micelles was observed by using a JEM2100 transmission electron microscope (JEOL, Japan).

Techniques: Functional Assay

(A) FT-IR and (B) 1 H NMR spectra of 6-APA, SA, and AM-Alg-APA.

Journal: ACS Omega

Article Title: Self-Assembly of Alginate-Grafted Penicillanic Acid Derivatives into Antibacterial Micelles for Controlled Drug Delivery

doi: 10.1021/acsomega.5c10841

Figure Lengend Snippet: (A) FT-IR and (B) 1 H NMR spectra of 6-APA, SA, and AM-Alg-APA.

Article Snippet: The morphology of the resulting AM-Alg-APA self-assembled micelles was observed by using a JEM2100 transmission electron microscope (JEOL, Japan).

Techniques:

(A) XPS spectra of AM-Alg-APA and SA; XPS N 1s narrow scans of (B) AM-Alg-APA and (C) SA; and XPS C 1s narrow scans of (D) AM-Alg-APA and (E) SA.

Journal: ACS Omega

Article Title: Self-Assembly of Alginate-Grafted Penicillanic Acid Derivatives into Antibacterial Micelles for Controlled Drug Delivery

doi: 10.1021/acsomega.5c10841

Figure Lengend Snippet: (A) XPS spectra of AM-Alg-APA and SA; XPS N 1s narrow scans of (B) AM-Alg-APA and (C) SA; and XPS C 1s narrow scans of (D) AM-Alg-APA and (E) SA.

Article Snippet: The morphology of the resulting AM-Alg-APA self-assembled micelles was observed by using a JEM2100 transmission electron microscope (JEOL, Japan).

Techniques:

(A) X-ray diffractograms, (B) TGA curves, and (C) DTG curves of SA and AM-Alg-APA.

Journal: ACS Omega

Article Title: Self-Assembly of Alginate-Grafted Penicillanic Acid Derivatives into Antibacterial Micelles for Controlled Drug Delivery

doi: 10.1021/acsomega.5c10841

Figure Lengend Snippet: (A) X-ray diffractograms, (B) TGA curves, and (C) DTG curves of SA and AM-Alg-APA.

Article Snippet: The morphology of the resulting AM-Alg-APA self-assembled micelles was observed by using a JEM2100 transmission electron microscope (JEOL, Japan).

Techniques:

(A) Pyrene fluorescence spectra of AM-Alg-APA in aqueous solution with various concentrations; (B) Plots of pyrene fluorescence intensity I 1 /I 3 vs the concentration of SA and AM-Alg-APA solutions; (C) Plots of conductivity (κ) as a function of the concentration of SA and AM-Alg-APA solutions.

Journal: ACS Omega

Article Title: Self-Assembly of Alginate-Grafted Penicillanic Acid Derivatives into Antibacterial Micelles for Controlled Drug Delivery

doi: 10.1021/acsomega.5c10841

Figure Lengend Snippet: (A) Pyrene fluorescence spectra of AM-Alg-APA in aqueous solution with various concentrations; (B) Plots of pyrene fluorescence intensity I 1 /I 3 vs the concentration of SA and AM-Alg-APA solutions; (C) Plots of conductivity (κ) as a function of the concentration of SA and AM-Alg-APA solutions.

Article Snippet: The morphology of the resulting AM-Alg-APA self-assembled micelles was observed by using a JEM2100 transmission electron microscope (JEOL, Japan).

Techniques: Fluorescence, Concentration Assay

(A) TEM image, (B) histogram representing size distribution derived from the TEM image, (C) hydrodynamic diameter distribution, and (D) Zeta potential distribution of AM-Alg-APA self-assembled micelles.

Journal: ACS Omega

Article Title: Self-Assembly of Alginate-Grafted Penicillanic Acid Derivatives into Antibacterial Micelles for Controlled Drug Delivery

doi: 10.1021/acsomega.5c10841

Figure Lengend Snippet: (A) TEM image, (B) histogram representing size distribution derived from the TEM image, (C) hydrodynamic diameter distribution, and (D) Zeta potential distribution of AM-Alg-APA self-assembled micelles.

Article Snippet: The morphology of the resulting AM-Alg-APA self-assembled micelles was observed by using a JEM2100 transmission electron microscope (JEOL, Japan).

Techniques: Derivative Assay, Zeta Potential Analyzer

Effects of (A) pH and (B) ionic strength on the hydrodynamic diameter and Zeta potential of AM-Alg-APA self-assembled micelles.

Journal: ACS Omega

Article Title: Self-Assembly of Alginate-Grafted Penicillanic Acid Derivatives into Antibacterial Micelles for Controlled Drug Delivery

doi: 10.1021/acsomega.5c10841

Figure Lengend Snippet: Effects of (A) pH and (B) ionic strength on the hydrodynamic diameter and Zeta potential of AM-Alg-APA self-assembled micelles.

Article Snippet: The morphology of the resulting AM-Alg-APA self-assembled micelles was observed by using a JEM2100 transmission electron microscope (JEOL, Japan).

Techniques: Zeta Potential Analyzer

In vitro cumulative release profiles of TCA-loaded SA micelles and TCA-loaded AM-Alg-APA self-assembled micelles in PBS (pH 7.4 and 5.0) at 37 °C. *Represents p < 0.05, indicating a significant difference (error bars denote the standard deviation of three replicates).

Journal: ACS Omega

Article Title: Self-Assembly of Alginate-Grafted Penicillanic Acid Derivatives into Antibacterial Micelles for Controlled Drug Delivery

doi: 10.1021/acsomega.5c10841

Figure Lengend Snippet: In vitro cumulative release profiles of TCA-loaded SA micelles and TCA-loaded AM-Alg-APA self-assembled micelles in PBS (pH 7.4 and 5.0) at 37 °C. *Represents p < 0.05, indicating a significant difference (error bars denote the standard deviation of three replicates).

Article Snippet: The morphology of the resulting AM-Alg-APA self-assembled micelles was observed by using a JEM2100 transmission electron microscope (JEOL, Japan).

Techniques: In Vitro, Standard Deviation

(A) In vitro cytotoxicity of SA and AM-Alg-APA self-assembled micelles at different concentrations on MC3T3-E1 cells after 48 h culture; Calcein-AM staining microscopic images of MC3T3-E1 cells cultured for 48 h in AM-Alg-APA self-assembled micelle solution: (B) bright field, (C) red channel, and (D) green channel.

Journal: ACS Omega

Article Title: Self-Assembly of Alginate-Grafted Penicillanic Acid Derivatives into Antibacterial Micelles for Controlled Drug Delivery

doi: 10.1021/acsomega.5c10841

Figure Lengend Snippet: (A) In vitro cytotoxicity of SA and AM-Alg-APA self-assembled micelles at different concentrations on MC3T3-E1 cells after 48 h culture; Calcein-AM staining microscopic images of MC3T3-E1 cells cultured for 48 h in AM-Alg-APA self-assembled micelle solution: (B) bright field, (C) red channel, and (D) green channel.

Article Snippet: The morphology of the resulting AM-Alg-APA self-assembled micelles was observed by using a JEM2100 transmission electron microscope (JEOL, Japan).

Techniques: In Vitro, Staining, Cell Culture